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Home/Compounds/Argireline

Cosmetic

Argireline

Also known as: Acetyl Hexapeptide-3 · Acetyl Hexapeptide-8

Topical hexapeptide marketed for temporary softening of expression lines.

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Grade C

Animal studies only

Human studies26

PubMed citations30

Routetopical

Regulatory (US)Research only

Last verified2 days ago

Mechanism of action

Acetyl-EEMQRR-NH2. Derived from the N-terminus of SNAP-25; proposed to interfere with SNARE complex formation and thereby reduce muscle-contraction wrinkles when delivered topically.

Evidence summary

Human studies

PubMed citations

Clinical trials

Evidence grade

Evidence summary in progress. See the citations section below for the underlying research papers.

Dosing protocols

Educational information only. Consult a licensed provider before using any peptide.

Administration routes

topical

Side effects & safety

No FDA label or editorial side-effect profile is on file for this compound yet. See the clinical trials and citations sections for study-reported safety data.

Interactions

No documented drug interactions on file.

Regulatory status

United States

Not FDA approved

Not FDA approved as a drug. Used as a cosmetic ingredient.

Compounding

Not permitted

Not available via 503A/503B compounding pharmacies.

Regulatory data last verified 4/19/2026

Clinical trials

NCT06143033A Clinical Trial to Evaluate the Effects of an Eye Serum on Improving the Appearance of the Periorbital AreaCompleted · N/A · Periorbital Area · n=35 NCT03878381Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care CreamCompleted · Phase 1 · Skin Care · n=10 NCT02597777Pilot Randomized Double-Blind Controlled Trial of Topical Acetyl Hexapeptide-8 and the Cosmetic Appearance of Oily SkinCompleted · N/A · Oily Skin · n=14 NCT01750346Placebo Controlled Double Blind Study of Acetyl Hexapeptide-8 in Treatment of BlepharospasmTerminated · Phase 2 · Focal Dystonia · n=8 NCT00942851A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of BlepharospasmCompleted · Phase 1 · Focal Dystonia · n=24 NCT01381484Efficacy and Safety of Topical Argireline in the Treatment of Periorbital WrinklesCompleted · Phase 3 · Wrinkles · n=70

Citations

PMID 41657122Dikmen Kucuk S, Jabet P et al. · Cosmetic potential of Ganoderma lucidum (Reishi) extract in a topical cream formulation.International journal of cosmetic science (2026)Human PMID 41551769Rong G, Fan Q et al. · Fluorous oligoarginines as supra-enhancers for intracellular and transdermal peptide delivery.Bioactive materials (2026)PMID 41628877Feng M, Wu C et al. · Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients.International journal of biological macromolecules (2026)Human PMID 40626902Wang Z, Zhang L et al. · Dual-function supramolecular system of α-hydroxy acid-based ionic liquids and peptides for enhanced anti-aging transdermal delivery.Journal of materials chemistry. B (2025)Human PMID 40176351Jiang X, Wang W et al. · BAK and ARG Have Moisturizing, Anti-Inflammatory, Antioxidant, and Antioxidant Bioactivities, in the Zebrafish Model.Journal of cosmetic dermatology (2025)Human PMID 40565185Zdrada-Nowak J, Surgiel-Gemza A et al. · Acetyl Hexapeptide-8 in Cosmeceuticals-A Review of Skin Permeability and Efficacy.International journal of molecular sciences (2025)Human PMID 40522284Wang M, Liu T et al. · A Supramolecular System of Bioactive Ionic Liquid, Peony Extract, and Peptide for Enhanced Permeability and Synergistic Skincare Benefits.Chemistry (Weinheim an der Bergstrasse, Germany) (2025)Human PMID 38314369Velazco de Maldonado GJ, Suárez-Vega DV et al. · Polydioxanone Bioactive Sutures-Acetyl Hexapeptide-8 (Argireline): An Intelligent System for Controlled Release in Facial Harmonization.Journal of cutaneous and aesthetic surgery (2024)Human PMID 39496132Lupin M, Bjerring P et al. · INDIVIDUAL ARTICLE: Real-World Clinical Experience With a Neuro-Peptide Serum in Combination With Botulinum Toxin Type-A Injections.Journal of drugs in dermatology : JDD (2024)Human PMID 38376906Olsson SE, Sreepad B et al. · Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis.JMIR dermatology (2024)PMID 23607739Wang Y, Wang M et al. · The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects.Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology (2024)Human PMID 39233460Chan LKW, Lee KWA et al. · Cosmeceuticals in photoaging: A review.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2024)Human PMID 38598772Hou J, Wei W et al. · Developing Plant Exosomes as an Advanced Delivery System for Cosmetic Peptide.ACS applied bio materials (2024)Human PMID 37752675Wyrzykowski D, Wieczorek R et al. · Influence of the modification of the cosmetic peptide Argireline on the affinity toward copper(II) ions.Journal of peptide science : an official publication of the European Peptide Society (2024)Human PMID 38024099Henseler H · Investigating the effects of Argireline in a skin serum containing hyaluronic acids on skin surface wrinkles using the Visia® Complexion Analysis camera system for objective skin analysis.GMS Interdisciplinary plastic and reconstructive surgery DGPW (2023)Human PMID 33748252Chen CF, Liu J et al. · Mycobacterium abscessus infection after facial injection of argireline: A case report.World journal of clinical cases (2021)Human PMID 34284359Mestre R, García N et al. · 3D-bioengineered model of human skeletal muscle tissue with phenotypic features of aging for drug testing purposes.Biofabrication (2021)Human PMID 31952064Lim SH, Tiew WJ et al. · Geometrical optimisation of a personalised microneedle eye patch for transdermal delivery of anti-wrinkle small peptide.Biofabrication (2021)Human PMID 33849044Wu Y, Cao K et al. · Protective and Anti-Aging Effects of 5 Cosmeceutical Peptide Mixtures on Hydrogen Peroxide-Induced Premature Senescence in Human Skin Fibroblasts.Skin pharmacology and physiology (2021)Human PMID 33151254Palmieri B, Noviello A et al. · Skin scars and wrinkles temporary camouflage in dermatology and oncoesthetics: focus on acetyl hexapeptide-8.La Clinica terapeutica (2021)Human

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