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Home/Compounds/BPC-157
Healing

BPC-157

Also known as: Body Protection Compound-157 · Pentadecapeptide BPC 157

Gastric pentadecapeptide studied for tissue healing, gut protection, and injury recovery.

C
Grade C
Animal studies only
Human studies25
PubMed citations30
Typical dose200 mcg – 500 mcg
Routesubcutaneous, intramuscular, oral
Regulatory (US)Research only
Last verifiedyesterday
TL;DR · 30-second summary
  • Accelerated tendon and ligament healing in rat models
  • Protective effects on gastric mucosa
  • Enhanced muscle healing after injury
  • Neuroprotective properties in animal studies

Mechanism of action

Derived from human gastric juice, promotes angiogenesis, modulates nitric oxide system, upregulates growth hormone receptors, and accelerates tendon-to-bone healing through multiple pathways.

Evidence summary

25
Human studies
30
PubMed citations
0
Clinical trials
C
Evidence grade

Extensive animal research showing accelerated healing of tendons, ligaments, muscle, and GI tract. No published human clinical trials to date, though anecdotal reports are widespread.

Dosing protocols

Educational information only. Consult a licensed provider before using any peptide.
Dose range
200 mcg – 500 mcg

Common research protocols use 200-500mcg 1-2x daily, either systemically or locally near injury site. No established human dosing.

Administration routes
subcutaneousintramuscularoral

Side effects & safety

Reported side effects
Limited data - generally well-tolerated in animal studiesPossible injection site reactions
Contraindications
  • Unknown - insufficient human data
  • Use caution with active cancer due to angiogenic effects

Interactions

No documented drug interactions on file.

Regulatory status

United States
Not FDA approved

Not FDA approved. Research chemical status. Recently added to FDA Category 2 list (cannot be compounded).

Compounding
Not permitted

Not available via 503A/503B compounding pharmacies.

Regulatory data last verified 4/17/2026

Citations

PMID 41490200Rahman OF, Lee SJ et al. · Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews (2026)HumanPMID 41898733Yuan C, Demers A et al. · From Regeneration to Analgesia: The Role of BPC-157 in Tissue Repair and Pain Management.International journal of molecular sciences (2026)HumanPMID 41476424Mayfield CK, Bolia IK et al. · Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.The American journal of sports medicine (2026)HumanPMID 40131143Lee E, Burgess K · Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study.Alternative therapies in health and medicine (2025)HumanPMID 40756949Vasireddi N, Hahamyan H et al. · Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review.HSS journal : the musculoskeletal journal of Hospital for Special Surgery (2025)HumanPMID 39265666DeFoor MT, Dekker TJ · Injectable Therapeutic Peptides-An Adjunct to Regenerative Medicine and Sports Performance?Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association (2025)HumanPMID 40005999Józwiak M, Bauer M et al. · Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent Review.Pharmaceuticals (Basel, Switzerland) (2025)HumanPMID 40789979McGuire FP, Martinez R et al. · Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing.Current reviews in musculoskeletal medicine (2025)HumanPMID 38583442Vukusic D, Zenko Sever A et al. · Duodenocolic fistula healing by pentadecapeptide BPC 157 in rats. A cytoprotection viewpoint.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society (2024)PMID 34798584Deek SA · BPC 157 as Potential Treatment for COVID-19.Medical hypotheses (2024)HumanPMID 38675421Sikiric P, Boban Blagaic A et al. · The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity.Pharmaceuticals (Basel, Switzerland) (2024)HumanPMID 39325560Lee E, Walker C et al. · Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study.Alternative therapies in health and medicine (2024)HumanPMID 39204186Bajramagic S, Sever M et al. · Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats-A Review.Pharmaceuticals (Basel, Switzerland) (2024)HumanPMID 37513963Sikiric P, Kokot A et al. · Stable Gastric Pentadecapeptide BPC 157-Possible Novel Therapy of Glaucoma and Other Ocular Conditions.Pharmaceuticals (Basel, Switzerland) (2023)HumanPMID 36359218Sikiric P, Udovicic M et al. · Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation.Biomedicines (2022)HumanPMID 35203478Barisic I, Balenovic D et al. · Stable Gastric Pentadecapeptide BPC 157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats.Biomedicines (2022)PMID 36551977Staresinic M, Japjec M et al. · Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle.Biomedicines (2022)HumanPMID 34380875Vukojevic J, Milavić M et al. · Pentadecapeptide BPC 157 and the central nervous system.Neural regeneration research (2021)HumanPMID 32329684Sikiric P, Drmic D et al. · Fistulas Healing. Stable Gastric Pentadecapeptide BPC 157 Therapy.Current pharmaceutical design (2021)HumanPMID 34267654Seiwerth S, Milavic M et al. · Stable Gastric Pentadecapeptide BPC 157 and Wound Healing.Frontiers in pharmacology (2021)Human

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