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Home/Compounds/Carbetocin
OtherRx required

Carbetocin

Also known as: Duratocin · Pabal

Long-acting synthetic oxytocin analog used for prevention of postpartum hemorrhage; approved in many countries, not FDA approved.

B
Grade B
Human observational studies
Human studies27
PubMed citations29
Routeintramuscular, intravenous
Regulatory (US)Rx required
Last verified2 days ago

Mechanism of action

Oxytocin analog with a deamino modification and carbon substitution. Longer half-life than oxytocin; heat-stable formulation (Pabal) for low-resource settings.

Evidence summary

27
Human studies
29
PubMed citations
25
Clinical trials
B
Evidence grade

Evidence summary in progress. See the citations section below for the underlying research papers.

Dosing protocols

Educational information only. Consult a licensed provider before using any peptide.
Administration routes
intramuscularintravenous

Side effects & safety

No FDA label or editorial side-effect profile is on file for this compound yet. See the clinical trials and citations sections for study-reported safety data.

Interactions

No documented drug interactions on file.

Regulatory status

United States
Not FDA approved

Not FDA approved. Approved in Canada, Europe, and many other countries for prevention of postpartum hemorrhage.

Compounding
Not permitted

Not available via 503A/503B compounding pharmacies.

Regulatory data last verified 4/19/2026

Clinical trials

NCT07401524Carbetocin Administration for the Prevention of Postpartum Hemorrhage in Twin Deliveries: A Randomized Controlled TrialNot Yet Recruiting · Phase 4 · Postpartum Hemorrhage · n=120NCT06285409Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human MyometriumRecruiting · N/A · Postpartum Hemorrhage · n=32NCT06333340Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery: a Randomized Controlled TrialRecruiting · N/A · Post Partum Hemorrhage · n=160NCT07187544Effect of Co-administration of Carbetocin and Calcium Chloride on Uterine Tone in Patients Undergoing Elective Cesarean Delivery: a Double-blind Randomized Control TrialRecruiting · N/A · Postpartum Hemorrhage (Primary) · n=120NCT07380529Comparison of the Effect of Carbetocin Versus Oxytocin in the Prevention of Postpartum Hemorrhage After Emergency Caesarean Section in Antenatal Low-risk PatientsCompleted · N/A · Postpartum Hemorrhage \(PPH\) · n=300NCT03899961The Clinical Carbetocin Myocardium Trial Part 2Completed · Phase 4 · Pregnancy Complications · n=240NCT07390864Intramyometrial Ergometrine Injection Versus Intramyometrial Carbetocin Injection to Decrease Blood Loss During and After Abdominal Myomectomy: A Randomized Clinical TrialRecruiting · N/A · Myoma;Uterus · n=40NCT07353281Carbetocin Versus Misoprostol for the Prevention of Postpartum Hemorrhage After Vaginal Delivery in Women With Risk Factors: A Prospective Randomized StudyNot Yet Recruiting · N/A · Postpartum Complication · n=146NCT07318467Prophylactic Regimen of Intravenous Oxytocin, Intravenous Tranexamic Acid, and Intramuscular Ergot Derivative for Primary Prevention of Postpartum Hemorrhage in Intrapartum Cesarean Section Versus Intravenous Carbetocin AloneNot Yet Recruiting · N/A · Post Partum Hemorrhage · n=80NCT06420297A Long-term, Open-label Extension Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi SyndromeEnrolling By Invitation · Phase 3 · Hyperphagia in Prader-Willi Syndrome · n=160NCT06930391Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium: An Ex-Vivo StudyRecruiting · N/A · Postpartum Hemorrhage (Primary) · n=40NCT06776926When Should Carbetocin be Administered to Prevent Postpartum Hemorrhage After Normal Vaginal Delivery?Completed · N/A · Postpartum Hemorrhage · n=200

Showing 12 of 25 indexed studies. View all on ClinicalTrials.gov →

Citations

PMID 41065225Baştemur AG, İpek G et al. · Oxytocin versus carbetocin for preventing postpartum hemorrhage in patients with polyhydramnios during cesarean delivery: A retrospective cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (2026)HumanPMID 39764811Onwochei DN, Desai N et al. · Uterotonics update.Best practice & research. Clinical anaesthesiology (2025)HumanPMID 40772429Bekkenes ME, Jørgensen MM et al. · Effects of Prophylactic Oxytocin or Carbetocin on Troponin Release and Postpartum Haemorrhage at Planned Caesarean Delivery: A Double-Blind Randomised Controlled Trial.BJOG : an international journal of obstetrics and gynaecology (2025)HumanPMID 40237648Gallos ID, Yunas I et al. · Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis.The Cochrane database of systematic reviews (2025)HumanPMID 38462248Hersh AR, Carroli G et al. · Third stage of labor: evidence-based practice for prevention of adverse maternal and neonatal outcomes.American journal of obstetrics and gynecology (2024)HumanPMID 38428678Astete M, Lacassie HJ · Uterotonics, magnesium sulphate and antibiotics during childbirth and peripartum: Important obstetric drugs for the anaesthesiologist.Revista espanola de anestesiologia y reanimacion (2024)HumanPMID 39722234Maged AM, El-Goly NA et al. · A systematic review and meta-analysis of randomized trials comparing carbetocin to oxytocin in prevention of postpartum hemorrhage after cesarean delivery in low-risk women.The journal of obstetrics and gynaecology research (2024)HumanPMID 36202701Cotter SP, Schwartz L et al. · The Prader-Willi Syndrome Anxiousness and Distress Behaviors Questionnaire: Development and Psychometric Validation.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research (2023)HumanPMID 36633570Roof E, Deal CL et al. · Intranasal Carbetocin Reduces Hyperphagia, Anxiousness, and Distress in Prader-Willi Syndrome: CARE-PWS Phase 3 Trial.The Journal of clinical endocrinology and metabolism (2023)HumanPMID 37568196Hofmeyr GJ · Novel concepts and improvisation for treating postpartum haemorrhage: a narrative review of emerging techniques.Reproductive health (2023)HumanPMID 36028160Jones AJ, Federspiel JJ et al. · Preventing postpartum hemorrhage with combined therapy rather than oxytocin alone.American journal of obstetrics & gynecology MFM (2023)HumanPMID 35102109Miller HE, Ansari JR · Uterine atony.Current opinion in obstetrics & gynecology (2022)HumanPMID 35770122Huang X, Xue W et al. · Effect of Carbetocin on Postpartum Hemorrhage after Vaginal Delivery: A Meta-Analysis.Computational and mathematical methods in medicine (2022)HumanPMID 35762809Ameh C, Althabe F · Improving postpartum hemorrhage care: Policy, practice, and research.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (2022)HumanPMID 36002156Day A, Barclay P et al. · Is there a role for carbetocin in the prophylaxis of postpartum obstetric haemorrhage?Drug and therapeutics bulletin (2022)HumanPMID 36520799You JHS, Leung TY · Cost-effectiveness analysis of carbetocin for prevention of postpartum hemorrhage in a low-burden high-resource city of China.PloS one (2022)HumanPMID 33321392Muro BBD, Carnevale RF et al. · Effects of uterotonics on farrowing traits and piglet vitality: A systematic review and meta-analysis.Theriogenology (2021)PMID 31134574Wiśniewski K · Design of Oxytocin Analogs.Methods in molecular biology (Clifton, N.J.) (2020)HumanPMID 32039467Feduniw S, Warzecha D et al. · Epidemiology, prevention and management of early postpartum hemorrhage - a systematic review.Ginekologia polska (2020)HumanPMID 30411314Wohling J, Edge N et al. · Clinical and financial evaluation of carbetocin as postpartum haemorrhage prophylaxis at caesarean section: A retrospective cohort study.The Australian & New Zealand journal of obstetrics & gynaecology (2020)Human

Showing 20 of 29 papers. View all on PubMed →