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Home/Compounds/Colivelin
Cognitive

Colivelin

Also known as: CLN

Synthetic hybrid peptide combining an AGA-modified humanin fragment with ADNF-9; studied preclinically for neuroprotection.

C
Grade C
Animal studies only
Human studies24
PubMed citations29
Regulatory (US)Research only
Last verified2 days ago

Mechanism of action

AGA-(C8R)HNG17 fused with ADNF-9. Much more potent than either parent peptide in neuronal-survival assays.

Evidence summary

24
Human studies
29
PubMed citations
0
Clinical trials
C
Evidence grade

Evidence summary in progress. See the citations section below for the underlying research papers.

Dosing protocols

Educational information only. Consult a licensed provider before using any peptide.

Side effects & safety

No FDA label or editorial side-effect profile is on file for this compound yet. See the clinical trials and citations sections for study-reported safety data.

Interactions

No documented drug interactions on file.

Regulatory status

United States
Not FDA approved

Not FDA approved. Research peptide.

Compounding
Not permitted

Not available via 503A/503B compounding pharmacies.

Regulatory data last verified 4/19/2026

Clinical trials

No indexed ClinicalTrials.gov studies for Colivelin. This usually means the compound isn't being studied under an IND — check the citations section for peer-reviewed research instead.

Citations

PMID 39806334Sun L, Li X et al. · Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis.Journal of translational medicine (2025)HumanPMID 40055623Liu Y, Gong Z et al. · Esketamine attenuates traumatic brain injury by modulating STAT3-mediated Glycolysis and immune responses.BMC neuroscience (2025)PMID 40311103Marastoni D, Colato E et al. · Intrathecal Inflammatory Profile and Gray Matter Damage Predict Progression Independent of Relapse Activity in Early Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation (2025)HumanPMID 40769849Xu S, Zhu J et al. · Reticuline modulates astrocyte and microglial responses to enhance prognosis after traumatic brain injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2025)PMID 39656809Li X, Qi X et al. · Efficacy of nintedanib as a host-directed therapy candidate in the treatment of tuberculosis.The Journal of antimicrobial chemotherapy (2025)PMID 39067192Lai M, Sun S et al. · Sanfeng Tongqiao Dripping Pills alleviate House Dust Mite-induced allergic rhinitis in mice by inhibiting Th2 differentiation and repairing the nasal epithelial barrier.Phytomedicine : international journal of phytotherapy and phytopharmacology (2024)HumanPMID 39533388Yuan P, Huang ZH et al. · A 18F-FDG PET/CT-based deep learning-radiomics-clinical model for prediction of cervical lymph node metastasis in esophageal squamous cell carcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society (2024)HumanPMID 38842347Mehta NK, Rakhra K et al. · CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity.Cancer immunology research (2024)HumanPMID 39265445Yao Y, Song L et al. · Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling.Phytomedicine : international journal of phytotherapy and phytopharmacology (2024)PMID 39675786Gong Y, Liu S et al. · Efficacy of initial combination with belimumab in newly diagnosed childhood-onset lupus nephritis: a single-centre historical control study.Lupus science & medicine (2024)HumanPMID 38552377Peng H, Lin X et al. · Epigallocatechin gallate suppresses mitotic clonal expansion and adipogenic differentiation of preadipocytes through impeding JAK2/STAT3-mediated transcriptional cascades.Phytomedicine : international journal of phytotherapy and phytopharmacology (2024)PMID 39096281Ji R, Hao Z et al. · Fisetin Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglia/Macrophage M1 Polarization and JAK2/STAT3 Signaling Pathway.Journal of agricultural and food chemistry (2024)HumanPMID 39602512Danaher P, Hasle N et al. · Childhood-onset lupus nephritis is characterized by complex interactions between kidney stroma and infiltrating immune cells.Science translational medicine (2024)HumanPMID 37022340Huber RJ · Recent insights into the networking of CLN genes and proteins in mammalian cells.Journal of neurochemistry (2023)HumanPMID 36933872You Y, Chen X et al. · Jiawei Yanghe Decoction suppresses breast cancer by regulating immune responses via JAK2/STAT3 signaling pathway.Journal of ethnopharmacology (2023)HumanPMID 37586770Meetze K, Mehta NK et al. · CLN-978, a novel half-life extended CD19/CD3/HSA-specific T cell-engaging antibody construct with potent activity against B-cell malignancies with low CD19 expression.Journal for immunotherapy of cancer (2023)HumanPMID 36119052Urban C, Hayes HV et al. · Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.Frontiers in immunology (2022)HumanPMID 33242182Specchio N, Ferretti A et al. · Neuronal Ceroid Lipofuscinosis: Potential for Targeted Therapy.Drugs (2021)HumanPMID 30559253Zanos S · Closed-Loop Neuromodulation in Physiological and Translational Research.Cold Spring Harbor perspectives in medicine (2020)HumanPMID 31374230Zhao H, Feng Y et al. · Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway.Neuroscience (2020)Human

Showing 20 of 29 papers. View all on PubMed →