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Home/Compounds/Cortexin
Cognitive

Cortexin

Also known as: Cortexinum

Peptide preparation from bovine or porcine cerebral cortex; approved in Russia for CNS indications.

C
Grade C
Animal studies only
Human studies24
PubMed citations30
Routeintramuscular
Regulatory (US)Research only
Last verified2 days ago

Mechanism of action

Low-molecular-weight peptide mixture proposed to exert neurotrophic and metabolic effects on cortical neurons.

Evidence summary

24
Human studies
30
PubMed citations
0
Clinical trials
C
Evidence grade

Evidence summary in progress. See the citations section below for the underlying research papers.

Dosing protocols

Educational information only. Consult a licensed provider before using any peptide.
Administration routes
intramuscular

Side effects & safety

No FDA label or editorial side-effect profile is on file for this compound yet. See the clinical trials and citations sections for study-reported safety data.

Interactions

No documented drug interactions on file.

Regulatory status

United States
Not FDA approved

Not FDA approved. Approved in Russia; limited Western clinical-trial literature.

Compounding
Not permitted

Not available via 503A/503B compounding pharmacies.

Regulatory data last verified 4/19/2026

Clinical trials

No indexed ClinicalTrials.gov studies for Cortexin. This usually means the compound isn't being studied under an IND — check the citations section for peer-reviewed research instead.

Citations

PMID 40783844Guven C, Türk A et al. · Cortexin modulates OPG/RANK/RANKL and TRPC1 expression in cerebral ischemia-reperfusion injury.Neurological research (2026)PMID 41782536Schastnyy ED · [Efficacy and safety of Cortexin as additional therapy in patients with depressive disorder].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2026)HumanPMID 41524350Fedin AI, Khairova EN et al. · [Therapeutic equivalence of intravenous and intramuscular dosage forms of Cortexin in ischemic strokes].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2026)HumanPMID 39954108Sharifi S, Katamanin O et al. · Exploring the psychodermatologic burden and associated psychiatric manifestations in rosacea: a systemic review.Archives of dermatological research (2025)HumanPMID 40299434Kurkin DV, Bakulin DA et al. · Neurotropic Effects of Cortexin on Models of Mental and Physical Developmental Delay.Biomedicines (2025)HumanPMID 38261281Nemkova SA, Boldyrev VG · [Early differential diagnosis and restorative treatment of cerebral palsy].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2024)HumanPMID 39731376Degtyareva VG, Drobyshev VA et al. · [The effectiveness of rehabilitation measures using the drug Cortexin in children with neuropsychiatric pathology].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2024)HumanPMID 39690562Kuznetsova EB, Selivanova JV et al. · [Evaluation of the effectiveness of the drug Cortexin in combination with the use of the application Aphasia.No (Afaziyam.Net) in the correction of speech disorders in patients with cerebral infarction].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2024)HumanPMID 38188053Boksha I, Savushkina O et al. · Late onset psychosis treatment with adjunctive medicines.Frontiers in psychiatry (2024)PMID 37818733Ziganshina LE, Abakumova T et al. · Cerebrolysin for acute ischaemic stroke.The Cochrane database of systematic reviews (2023)HumanPMID 38147380Mashin VV, Belova LA et al. · [Results of a multicenter observational program to evaluate the effectiveness of complex therapy of patients with chronic cerebrovascular pathology with cognitive impairment with Cortexin and Neuromexol (CORNELia study)].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2023)HumanPMID 33834730V Kalmykova G, Chefranova ZY et al. · [Cortexin administration due to improvement of cognitive and behavioral disorders in children and teenagers with epilepsy].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2021)HumanPMID 34460162Kurkin DV, Morkovin EI et al. · [Antioxidant effect of cortexin, cerebrolysin and actovegin in rats with chronic cerebrovascular insufficiency].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2021)PMID 33449527Khabirov FA, Khaibullin TI et al. · [Comparison of the efficacy of Cellex and Cortexin in patients in the early recovery period of ischemic stroke].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2021)HumanPMID 34037354Balakireva EA, Klestova EO et al. · [Possibilities of neurotrophic therapy for delayed speech development].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2021)HumanPMID 32929929Tyurenkov IN, Kurkin DV et al. · [Comparative study of protective effects of Cortexin, Cerebrolysin and Actovegin on memory impairment, cerebral circulation and morphological changes in the hippocampus of rats with chronic brain ischemia].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2020)PMID 31626167Chutko LS, Surushkina SY et al. · [Cognitive disturbances in children with chronic tics and their treatment].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2020)HumanPMID 28617383Rodionova EY, Chutko LS et al. · [Сlinical and physiological characteristics and therapy asthenic disorders in adolescents girls].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2019)HumanPMID 29652302Zykov VP, Serebrennikova EB et al. · [Results of a multicenter study on the efficacy of cortexin in treatment of cognitive dysfunction in children].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2019)HumanPMID 31464285Safronova MN, Kovalenko AV et al. · [Combined neuroprotection in the treatment of post-stroke aphasia].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2019)Human

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