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Home/Compounds/Desmopressin
OtherFDA approvedRx required

Desmopressin

Also known as: DDAVP · Minirin · Nocdurna · Stimate
Brands: DDAVP · Nocdurna · Stimate · Minirin

Synthetic vasopressin analog used for diabetes insipidus, nocturnal enuresis, and mild hemophilia A / von Willebrand disease.

A
Grade A
Multiple human RCTs
Human studies24
PubMed citations30
Routeoral, intranasal, intravenous, subcutaneous
Regulatory (US)FDA approved · Rx
Last verified2 days ago

Mechanism of action

1-deamino-8-D-arginine vasopressin. Selective V2 receptor agonist (renal water retention) with minimal V1 pressor effect; also releases factor VIII and vWF from endothelium.

Evidence summary

24
Human studies
30
PubMed citations
25
Clinical trials
A
Evidence grade

Evidence summary in progress. See the citations section below for the underlying research papers.

Dosing protocols

Educational information only. Consult a licensed provider before using any peptide.
Administration routes
oralintranasalintravenoussubcutaneous

Side effects & safety

From the FDA label
Source
diarrheaheadachenausea

Terms pulled directly from the referenced source. We don't fabricate frequencies — when a label doesn't publish a percentage, we don't either.

Interactions

No documented drug interactions on file.

Regulatory status

United States
FDA approved

FDA approved for central diabetes insipidus, nocturnal enuresis, nocturia, and bleeding disorders (DDAVP, Nocdurna, Stimate)

Compounding
Not permitted

Not available via 503A/503B compounding pharmacies.

Regulatory data last verified 4/19/2026

Clinical trials

NCT04569591Desmopressin (DDAVP) Stimulation for 18F-FDG-PET Detection of Pituitary Adenoma in Cushing's DiseaseRecruiting · N/A · Cushing's Disease · n=22NCT06337838Bleeding Reduction in Acute and Chronic KidnEy patienTs Having Surgery (BRACKETS) Pilot TrialRecruiting · Phase 3 · Chronic Kidney Diseases · n=100NCT07292753Role of Vitamin D Supplementation Versus Desmopressin Versus Their Combination in the Treatment of Primary Monosymptomatic Nocturnal Enuresis in Children With Vitamin D Deficiency: A Randomized Clinical TrialCompleted · N/A · Nocturnal Enuresis · n=90NCT06771128Ginkgo Biloba Versus Desmopressin in Treatment of Children With Monosymptomatic Nocturnal Enuresis: A Randomized Prospective StudyCompleted · N/A · Nocturnal Enuresis in Children · n=398NCT04740645Post-authorisation Safety Study of NOCDURNA for the Symptomatic Treatment of Nocturia Due to Idiopathic Nocturnal Polyuria: A Multi-country Cohort Study Using Secondary DataCompleted · Adverse Drug Event · n=1099551NCT06635629Phase II Prospective Evaluation of Desmopressin Stimulation Test Performance in ACTH-dependent Cushing s SyndromeRecruiting · Phase 2 · Cushing Syndrome · n=140NCT07199894A Randomized Controlled Trial Comparing Mirabegron and Solifenacin Combination Therapy Versus Desmopressin Monotherapy in Treatment of Children With Primary Mono-Symptomatic Nocturnal EnuresisRecruiting · Phase 3 · Nocturnal Enuresis in Children · n=120NCT07179991Desmopressin Effect on Platelet Function Assessment by Thromboelastography (TEG 6) in Cardiac SurgeryNot Yet Recruiting · Intraoperative Bleeding · n=100NCT06622187Bleeding Prevention With Desmopressin for Allograft Kidney Biopsies: a Double-blind Randomized StudyEnrolling By Invitation · Phase 4 · Bleeding · n=96NCT07028645Is Uroflowmetry Useful in Assessing Response to Pharmacological Treatment in EnuresisActive Not Recruiting · Enuresis, Nocturnal · n=100NCT07012837Reducing Point-of-Care Transfusion Requirements With Prolonged Desmopressin in High-Bleeding-Risk Cardiac Surgery: A Multicentre Randomized Controlled Trial (REDES-BLEED)Not Yet Recruiting · Phase 3 · Adult Patients Undergoing Cardiac Surgery · n=112NCT06020495Systematic Use of DDAVP to Prevent Serum Sodium Overcorrection in Severe Hyponatremia: a Multicenter Open-label Randomized Controlled TrialRecruiting · Phase 3 · Hyponatremia · n=260

Showing 12 of 25 indexed studies. View all on ClinicalTrials.gov →

Citations

PMID 40494946Zhai R, Shao S et al. · Efficacy of desmopressin and enuresis alarm in the treatment of monosymptomatic nocturnal enuresis: a multicenter prospective randomized controlled study.Pediatric nephrology (Berlin, Germany) (2025)HumanPMID 40723839Reardon B, Pasalic L et al. · A Review of Desmopressin Use in Bleeding Disorders: An Unsung Hero?Biomolecules (2025)HumanPMID 38962315Chen X, Sun WJ et al. · A systematic review and meta-analysis assessing the efficacy of Tuina for nocturnal enuresis in children.Frontiers in pharmacology (2024)PMID 38992343Daniel MY, Ternisien C et al. · Type 2N von Willebrand disease: genotype drives different bleeding phenotypes and treatment needs.Journal of thrombosis and haemostasis : JTH (2024)HumanPMID 36793853Feng Z, Jing Z et al. · Exosomal STIMATE derived from type II alveolar epithelial cells controls metabolic reprogramming of tissue-resident alveolar macrophages.Theranostics (2023)HumanPMID 36742884Youssefy A, Ghabasiah A et al. · The Effect of Desmopressin Intraoperatively on Hemorrhage During the Rhinoplasty Surgery.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India (2023)PMID 33786230Mutter CM, Smith T et al. · Diabetes Insipidus: Pathogenesis, Diagnosis, and Clinical Management.Cureus (2023)PMID 37649925Beltran A, Jaramillo AP et al. · Desmopressin as a Treatment in Patients With Von Willebrand Disease: A Systematic Review.Cureus (2023)PMID 35278886Sreeraman S, McKinlay S et al. · Efficacy of parenteral formulations of desmopressin in the treatment of bleeding disorders: A systematic review.Thrombosis research (2022)HumanPMID 35250842Wong CE, Wang WH et al. · Predicting the Need for Desmopressin Treatment During Inpatient and After Discharge Following Endoscopic Sellar Surgery.Frontiers in neurology (2022)PMID 32748210Andersen LK, Hvas AM et al. · Effect of Desmopressin on Platelet Dysfunction During Antiplatelet Therapy: A Systematic Review.Neurocritical care (2021)HumanPMID 32734186Achinger SG, Ayus JC · Use of Desmopressin in Hyponatremia: Foe and Friend.Kidney medicine (2020)PMID 30758840Karanth L, Barua A et al. · Desmopressin acetate (DDAVP) for preventing and treating acute bleeds during pregnancy in women with congenital bleeding disorders.The Cochrane database of systematic reviews (2019)HumanPMID 30004154Hews-Girard J, Rydz N et al. · Desmopressin in non-severe haemophilia A: Test-response and clinical outcomes in a single Canadian centre review.Haemophilia : the official journal of the World Federation of Hemophilia (2019)HumanPMID 27172867Chanson P, Salenave S · Diabetes insipidus and pregnancy.Annales d'endocrinologie (2017)HumanPMID 27622750Miesbach W, Berntorp E · Von Willebrand disease - the 'Dos' and 'Don'ts' in surgery.European journal of haematology (2017)HumanPMID 27213601Arndt C, Wulf H · [Hypernatremia - Diagnostics and therapy].Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS (2017)HumanPMID 26350784Karanth L, Barua A et al. · Desmopressin acetate (DDAVP) for preventing and treating acute bleeds during pregnancy in women with congenital bleeding disorders.The Cochrane database of systematic reviews (2016)HumanPMID 25107337Achinger SG, Arieff AI et al. · Desmopressin acetate (DDAVP)-associated hyponatremia and brain damage: a case series.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2015)HumanPMID 24703870Svensson PJ, Bergqvist PB et al. · Desmopressin in treatment of haematological disorders and in prevention of surgical bleeding.Blood reviews (2014)Human

Showing 20 of 30 papers. View all on PubMed →