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Home/Compounds/GHRP-2
Growth hormone

GHRP-2

Also known as: Growth Hormone Releasing Peptide 2 · Pralmorelin

Potent ghrelin mimetic with strongest GH release among GHRPs, moderate appetite effects.

B
Grade B
Human observational studies
Human studies22
PubMed citations30
Typical dose100 mcg – 300 mcg
Routesubcutaneous, intravenous
Regulatory (US)Compounding legal
Last verified4 days ago
TL;DR · 30-second summary
  • Highest GH release among GHRPs
  • Moderate appetite stimulation (less than GHRP-6)
  • Some cortisol/prolactin elevation
  • Approved in Japan for GH deficiency diagnosis

Mechanism of action

Synthetic hexapeptide ghrelin receptor agonist. Produces the highest GH release of the GHRP family with moderate effects on appetite, cortisol, and prolactin.

Evidence summary

22
Human studies
30
PubMed citations
0
Clinical trials
B
Evidence grade

Approved in Japan as diagnostic agent. Produces highest peak GH among GHRPs. Moderate side effect profile between GHRP-6 and ipamorelin.

Dosing protocols

Educational information only. Consult a licensed provider before using any peptide.
Dose range
100 mcg – 300 mcg

100-300mcg 2-3x daily. Often combined with CJC-1295 or sermorelin.

Administration routes
subcutaneousintravenous

Side effects & safety

Reported side effects
Increased appetiteWater retentionMild cortisol elevationFlushing
Contraindications
  • Active malignancy
  • Uncontrolled diabetes

Interactions

No documented drug interactions on file.

Regulatory status

United States
Not FDA approved

Not FDA approved. Research chemical.

Compounding
Permitted

Available through compounding pharmacies with valid prescription.

Regulatory data last verified 4/17/2026

Clinical trials

No indexed ClinicalTrials.gov studies for GHRP-2. This usually means the compound isn't being studied under an IND — check the citations section for peer-reviewed research instead.

Citations

PMID 35452483Seki Y, Ichihara A · Association between overweight and growth hormone secretion in patients with non-functioning pituitary tumors.PloS one (2022)HumanPMID 35795807Suzuki S, Ruike Y et al. · Clinical Usefulness of the Growth Hormone-Releasing Peptide-2 Test for Hypothalamic-Pituitary Disorder.Journal of the Endocrine Society (2022)PMID 35758863Celichowska M, Miedziaszczyk M et al. · Pharmacotherapy in Cachexia: A Review of Endocrine Abnormalities and Steroid Pharmacotherapy.Journal of pain & palliative care pharmacotherapy (2022)HumanPMID 32737681Kanhed AM, Patel DV et al. · Identification of potential Mpro inhibitors for the treatment of COVID-19 by using systematic virtual screening approach.Molecular diversity (2021)HumanPMID 34686480Tokumasu K, Ochi K et al. · Idiopathic combined adrenocorticotropin and growth hormone deficiency mimicking chronic fatigue syndrome.BMJ case reports (2021)HumanPMID 32257855Sinha DK, Balasubramanian A et al. · Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.Translational andrology and urology (2020)HumanPMID 30051972Popławska M, Błażewicz A · Identification of a novel growth hormone releasing peptide (a glycine analogue of GHRP-2) in a seized injection vial.Drug testing and analysis (2019)HumanPMID 30136411Gajda PM, Holm NB et al. · Glycine-modified growth hormone secretagogues identified in seized doping material.Drug testing and analysis (2019)PMID 28400207Sigalos JT, Pastuszak AW · The Safety and Efficacy of Growth Hormone Secretagogues.Sexual medicine reviews (2018)HumanPMID 25070016Fukuda I, Hizuka N et al. · Adult growth hormone deficiency: current concepts.Neurologia medico-chirurgica (2016)HumanPMID 26551992Vodnik M, Štrukelj B et al. · Ghrelin Receptor Ligands Reaching Clinical Trials: From Peptides to Peptidomimetics; from Agonists to Antagonists.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (2016)HumanPMID 24574167Timms M, Hall N et al. · A high-throughput LC-MS/MS screen for GHRP in equine and human urine, featuring peptide derivatization for improved chromatography.Drug testing and analysis (2015)HumanPMID 12938517Liu Q, Bai X et al. · The effect of GHRH, GHRP-2 and somatostatin on GH secretion by fetal pituitary.Journal of Tongji Medical University = Tong ji yi ke da xue xue bao (2015)HumanPMID 23101768Thomas A, Delahaut P et al. · Metabolism of growth hormone releasing peptides.Analytical chemistry (2013)HumanPMID 20878896Thomas A, Kohler M et al. · Identification of the growth-hormone-releasing peptide-2 (GHRP-2) in a nutritional supplement.Drug testing and analysis (2011)PMID 19907099Kamoi K, Minagawa S et al. · GH-releasing peptide-2 does not stimulate arginine vasopressin secretion in healthy men.Endocrine journal (2010)HumanPMID 17986630Granado M, Martín AI et al. · GH-releasing peptide-2 administration prevents liver inflammatory response in endotoxemia.American journal of physiology. Endocrinology and metabolism (2008)PMID 17609397Chihara K, Shimatsu A et al. · A simple diagnostic test using GH-releasing peptide-2 in adult GH deficiency.European journal of endocrinology (2007)HumanPMID 16033952Nasu R, Kumagai Y et al. · Physiologically based pharmacokinetic model for pralmorelin hydrochloride in rats.Drug metabolism and disposition: the biological fate of chemicals (2006)PMID 15699539Laferrère B, Abraham C et al. · Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men.The Journal of clinical endocrinology and metabolism (2005)Human

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