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Home/Compounds/Palmitoyl Tripeptide-1
Cosmetic

Palmitoyl Tripeptide-1

Also known as: Pal-GHK · Pal-GHK

Palmitoylated tripeptide (Gly-His-Lys) used in topical anti-aging formulations.

C
Grade C
Animal studies only
Human studies3
PubMed citations3
Routetopical
Regulatory (US)Research only
Last verified2 days ago

Mechanism of action

Palmitoyl-Gly-His-Lys. Palmitoyl modification of the GHK tripeptide improves lipid-phase skin penetration; proposed ECM stimulation.

Evidence summary

3
Human studies
3
PubMed citations
0
Clinical trials
C
Evidence grade

Evidence summary in progress. See the citations section below for the underlying research papers.

Dosing protocols

Educational information only. Consult a licensed provider before using any peptide.
Administration routes
topical

Side effects & safety

No FDA label or editorial side-effect profile is on file for this compound yet. See the clinical trials and citations sections for study-reported safety data.

Interactions

No documented drug interactions on file.

Regulatory status

United States
Not FDA approved

Not FDA approved. Cosmetic ingredient.

Compounding
Not permitted

Not available via 503A/503B compounding pharmacies.

Regulatory data last verified 4/19/2026

Clinical trials

No indexed ClinicalTrials.gov studies for Palmitoyl Tripeptide-1. This usually means the compound isn't being studied under an IND — check the citations section for peer-reviewed research instead.