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Home/Compounds/Selank
Cognitive

Selank

Also known as: TP-7 · Selanc

Synthetic tuftsin analog developed in Russia for anxiety and cognitive enhancement.

B
Grade B
Human observational studies
Human studies13
PubMed citations30
Typical dose250 mcg – 750 mcg
Routeintranasal, subcutaneous
Regulatory (US)Compounding legal
Last verified2 days ago
TL;DR · 30-second summary
  • Anxiolytic effects without sedation
  • No addiction or withdrawal observed
  • Improved cognitive function under stress
  • Immunomodulatory properties demonstrated

Mechanism of action

Modulates expression of brain-derived neurotrophic factor (BDNF), influences serotonin metabolism, and affects enkephalinase activity. May enhance GABAergic neurotransmission.

Evidence summary

13
Human studies
30
PubMed citations
2
Clinical trials
B
Evidence grade

Approved in Russia for anxiety and cognitive disorders. Human trials show anxiolytic effects comparable to benzodiazepines without sedation or dependence.

Dosing protocols

Educational information only. Consult a licensed provider before using any peptide.
Dose range
250 mcg – 750 mcg

Intranasal: 250-750mcg daily. Injectable: 250-500mcg daily. Typically used in 2-4 week cycles.

Administration routes
intranasalsubcutaneous

Side effects & safety

Reported side effects
Fatigue (rare)Nasal irritation (intranasal)Generally very well tolerated
Contraindications
  • Pregnancy
  • Breastfeeding
  • Known hypersensitivity

Interactions

No documented drug interactions on file.

Regulatory status

United States
Not FDA approved

Not FDA approved. Available as research peptide. Approved in Russia.

Compounding
Permitted

Available through compounding pharmacies with valid prescription.

Regulatory data last verified 4/17/2026

Citations

PMID 41490200Rahman OF, Lee SJ et al. · Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews (2026)HumanPMID 39611667Justin LD, Olukanni DO · Efficiency evaluation of wastewater treatment by three macrophytes using a pilot-constructed wetland system in Ota, Nigeria.Journal of water and health (2024)PMID 37677054Seibertz F, Rubio T et al. · Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development.Cardiovascular research (2023)HumanPMID 32621722Leonidovna YA, Aleksandrovna SM et al. · The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.Current reviews in clinical and experimental pharmacology (2022)PMID 36322304Konstantinopolsky MA, Chernyakova IV et al. · Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.Bulletin of experimental biology and medicine (2022)HumanPMID 34396551Doyno CR, White CM · Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank.Journal of clinical pharmacology (2022)HumanPMID 32314683Francesio A, Viora L et al. · Contrasting effects of high-starch and high-sugar diets on ruminal function in cattle.The Journal of dairy research (2021)PMID 33866673Pop-Ciutrila IS, Ghinea R et al. · The effects of thickness and shade on translucency parameters of contemporary, esthetic dental ceramics.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] (2021)HumanPMID 31625062Kolik LG, Nadorova AV et al. · Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.Bulletin of experimental biology and medicine (2020)PMID 28293190Filatova E, Kasian A et al. · GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells.Frontiers in pharmacology (2020)HumanPMID 31236882Mukhina AY, Medvedeva OA et al. · State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment.Bulletin of experimental biology and medicine (2019)PMID 30255741Vyunova TV, Andreeva L et al. · Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.Protein and peptide letters (2019)PMID 28702721Slominsky PA, Shadrina MI et al. · Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections (2018)PMID 27618679Kim HK, Choi JS et al. · A Novel Peptide Derived From Tissue-Type Plasminogen Activator Potently Inhibits Angiogenesis and Corneal Neovascularization.Journal of cellular biochemistry (2017)HumanPMID 28745220Siebert A, Gensicka-Kowalewska M et al. · Tuftsin - Properties and Analogs.Current medicinal chemistry (2017)HumanPMID 26356395Medvedev VE, Tereshchenko ON et al. · [Optimization of the treatment of anxiety disorders with selank].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2015)HumanPMID 21786679Kolomin TA, Shadrina MI et al. · [Changes in expression of the genes for chemokines, cytokines, and their receptors in response to selank and its fragments].Genetika (2011)PMID 21609736Kolomin T, Shadrina M et al. · Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank.Regulatory peptides (2011)HumanPMID 20919548Semenova TP, Kozlovskiĭ II et al. · [Experimental optimization of learning and memory processes by selank].Eksperimental'naia i klinicheskaia farmakologiia (2010)PMID 19882898Ershov FI, Uchakin PN et al. · [Antiviral activity of immunomodulator Selank in experimental influenza infection].Voprosy virusologii (2009)Human

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