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Home/Compounds/Sincalide
OtherFDA approvedRx required

Sincalide

Also known as: Kinevac · CCK-8
Brands: Kinevac

Synthetic C-terminal octapeptide of cholecystokinin used diagnostically to stimulate gallbladder contraction during scintigraphy.

A
Grade A
Multiple human RCTs
Human studies23
PubMed citations29
Routeintravenous
Regulatory (US)FDA approved · Rx
Last verified2 days ago

Mechanism of action

Synthetic version of cholecystokinin octapeptide (CCK-8). Binds CCK-A receptors on gallbladder smooth muscle, causing contraction.

Evidence summary

23
Human studies
29
PubMed citations
10
Clinical trials
A
Evidence grade

Evidence summary in progress. See the citations section below for the underlying research papers.

Dosing protocols

Educational information only. Consult a licensed provider before using any peptide.
Administration routes
intravenous

Side effects & safety

From the FDA label
Source
diarrheadizzinessheadachenausearashvomiting

Terms pulled directly from the referenced source. We don't fabricate frequencies — when a label doesn't publish a percentage, we don't either.

Interactions

No documented drug interactions on file.

Regulatory status

United States
FDA approved

FDA approved for gallbladder function imaging and to accelerate small-bowel transit (Kinevac)

Compounding
Not permitted

Not available via 503A/503B compounding pharmacies.

Regulatory data last verified 4/19/2026

Clinical trials

NCT07019519Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTSRecruiting · N/A · Postural Orthostatic Tachycardia Syndrome (POTS) · n=30NCT07018804Analysis of the Pathogenic Mechanism of Abnormal Airway Basal Cell Function in Bronchiolitis Obliterans Syndrome and Research on Targeted Treatment StrategiesEnrolling By Invitation · N/A · Bronchiolitis Obliterans Syndrome (BOS) · n=5NCT04567667Pharmacokinetics and Metabolism of [14C] BMS-986278 in Healthy Male ParticipantsCompleted · Phase 1 · Healthy Volunteers · n=9NCT00706381Thyroid Hormones Homeostasis and Energy Metabolism Changes During Stimulation of Endogenously Secreted Bile Acids (BAs)Completed · Phase 3 · Healthy Volunteers · n=31NCT02496221A Randomized, Double-blind, Single-dose, Placebo Controlled, 2-way Cross-over Study Evaluating Effect of Albiglutide on Cholecystokinin-induced Gallbladder Emptying in Fasting Healthy SubjectsCompleted · Phase 4 · Diabetes Mellitus, Type 2 · n=20NCT00685477Dose Response of Intravenous Sincalide (CCK-8) for Gallbladder EmptyingCompleted · N/A · Healthy · n=60NCT02507167Impact of Two Genetic Variants of OATP 1B3 or MRP 2 or Rifampin Mediated Transporter Inhibition on Systemic Disposition and Biological Efficacy of CCK-8 in 36 Healthy Male IndividualsCompleted · Phase 1 · Gastrointestinal Hormones · n=19NCT01656057The Impact of Gall Bladder Emptying and Bile Acids on the Human GLP-1-secretionCompleted · N/A · To Assess the Impact of Bile Acids on Human Glukagon-like-peptide-1 Secretion · n=10NCT00004414Sincalide (Cholecystokinin Octapeptide) Versus Placebo in Neonates at High Risk for Developing Parenteral Nutrition Associated CholestasisCompleted · N/A · Cholestasis · n=252NCT00737295Study to Investigate the Role of Ultrasound for Diagnosis of Biliary DyskinesiaTerminated · N/A · Biliary Dyskinesia · n=25

Citations

PMID 41219730Wang Q, Zhang W et al. · Schistosoma japonicum peptide SJMHE1 promotes peripheral nerve regeneration via macrophage migrasome-derived miR-26b-5p targeting the PTEN/AKT axis.Journal of translational medicine (2026)HumanPMID 40554675Dong H, Tian Y et al. · Integrative multiomic and immune profiling of lung adenocarcinoma: molecular landscapes, gene expression, and treatment response insights.The oncologist (2025)HumanPMID 40748469Cai S, Chen Y et al. · CD44-targeted therapy using mP6/Rg3 micelles inhibits oral cancer stem cell proliferation and migration.Cell biology and toxicology (2025)HumanPMID 40197161Zhao W, Chen Z et al. · Induction of apoptosis and hypoxic stress in malignant melanoma cells via graphene-mediated far-infrared radiation.BMC cancer (2025)HumanPMID 41189595Pan X, Li J et al. · SLC7A11-specific CAR-T cell therapy potently targets colorectal and pancreatic cancer.iScience (2025)HumanPMID 40196397Zhu Y, Zhang Z et al. · Mesoporous silica loaded with calcitonin gene-related peptide antagonist and curcumin alleviate oxidative stress and inflammation in the sciatic nerve.Frontiers in molecular biosciences (2025)PMID 40881350Zhou Q, Wang R · Cooperative targeting of NF-κB enhances ferroptosis-driven HCC therapy with Alisertib and Donafenib.Frontiers in cell and developmental biology (2025)HumanPMID 39521788Qiao X, Wang Z et al. · Combined metformin and simvastatin therapy inhibits SREBP2 maturation and alters energy metabolism in glioma.Cell death & disease (2024)HumanPMID 39301023Li J, Chen M et al. · TUBA1C orchestrates the immunosuppressive tumor microenvironment and resistance to immune checkpoint blockade in clear cell renal cell carcinoma.Frontiers in immunology (2024)HumanPMID 38948069Shi Z, Liu M et al. · A novel selenium analog of HDACi-based twin drug induces apoptosis and cell cycle arrest via CDC25A to improve prostate cancer therapy.Theranostics (2024)HumanPMID 37529698Wu X, Zhang Y et al. · Cuproptosis-related lncRNAs potentially predict prognosis and therapy sensitivity of breast cancer.Frontiers in pharmacology (2023)HumanPMID 37056559Wang H, Mu N et al. · Ultrasound-controlled MXene-based Schottky heterojunction improves anti-infection and osteogenesis properties.Theranostics (2023)PMID 36134483Ni L, Li P et al. · SERPINB8 and furin regulate ITGAX expression and affect the proliferation and invasion of melanoma cells.Experimental dermatology (2023)HumanPMID 37908731Zhou H, Yan L et al. · Tat-NTS peptide protects neurons against cerebral ischemia-reperfusion injury via ANXA1 SUMOylation in microglia.Theranostics (2023)HumanPMID 36171633Wang K, Dai X et al. · Peptide-based PROTAC degrader of FOXM1 suppresses cancer and decreases GLUT1 and PD-L1 expression.Journal of experimental & clinical cancer research : CR (2022)HumanPMID 34976211Tu J, Xu H et al. · Nintedanib enhances the efficacy of PD-L1 blockade by upregulating MHC-I and PD-L1 expression in tumor cells.Theranostics (2022)HumanPMID 36370897Bijle MN, Abdalla MM et al. · Synbiotic-fluoride synergism on enamel remineralization, cytotoxicity and genotoxicity.Journal of dentistry (2022)HumanPMID 34874343Vasireddi A, Nguyen NC · Sincalide-Stimulated Cholescintigraphy: A Retrospective Study and Proposal of a Modified Workflow.Clinical nuclear medicine (2021)HumanPMID 32111658Belanger E, Wolf SM et al. · Chemical Stability of Reconstituted Sincalide in Sterile Water Under 2 Different Storage Conditions.Journal of nuclear medicine technology (2021)PMID 31019045Ziessman HA · Sincalide: A Review of Clinical Utility, Proper Infusion Methodology, and Alternative Cholecystogogues.Journal of nuclear medicine technology (2020)Human

Showing 20 of 29 papers. View all on PubMed →