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Home/Compounds/DSIP
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DSIP

Also known as: Delta Sleep-Inducing Peptide

Neuropeptide that promotes delta wave sleep and may help with insomnia and stress.

C
Grade C
Animal studies only
Human studies22
PubMed citations30
Typical dose100 mcg – 300 mcg
Routesubcutaneous, intranasal, intravenous
Regulatory (US)Compounding legal
Last verified4 days ago
TL;DR · 30-second summary
  • Promotes delta wave sleep
  • May normalize cortisol patterns
  • Stress-protective effects in animal studies
  • No next-day sedation reported

Mechanism of action

Naturally occurring neuropeptide that promotes slow-wave (delta) sleep. Modulates cortisol, may affect pain perception, and has stress-protective properties.

Evidence summary

22
Human studies
30
PubMed citations
0
Clinical trials
C
Evidence grade

Early human studies showed improved sleep architecture. Research limited since 1990s. Popular for sleep optimization despite limited recent data.

Dosing protocols

Educational information only. Consult a licensed provider before using any peptide.
Dose range
100 mcg – 300 mcg

100-300mcg before bed. Can be used nightly or as needed. Some use intranasal.

Administration routes
subcutaneousintranasalintravenous

Side effects & safety

Reported side effects
Generally well toleratedPossible vivid dreamsMorning grogginess (rare)
Contraindications
  • Depression (theoretical)
  • Unknown - limited data

Interactions

No documented drug interactions on file.

Regulatory status

United States
Not FDA approved

Not FDA approved. Research peptide.

Compounding
Permitted

Available through compounding pharmacies with valid prescription.

Regulatory data last verified 4/17/2026

Clinical trials

No indexed ClinicalTrials.gov studies for DSIP. This usually means the compound isn't being studied under an IND — check the citations section for peer-reviewed research instead.

Citations

PMID 41490200Rahman OF, Lee SJ et al. · Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews (2026)HumanPMID 33918965Tukhovskaya EA, Shaykhutdinova ER et al. · DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion.Biomedicines (2024)HumanPMID 39444618Mu X, Qu L et al. · Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models.Frontiers in pharmacology (2024)HumanPMID 37884638Tatsumi T, Sasamoto K et al. · Practical N-to-C peptide synthesis with minimal protecting groups.Communications chemistry (2023)HumanPMID 25898718Mikhaleva II, Ivanov VT et al. · [Antioxidative and detoxifying effects of analogues of delta-sleep inducing peptide (DSIP)].Bioorganicheskaia khimiia (2015)PMID 22432135Sudakov KV, Umriukhin PE et al. · Delta-sleep inducing peptide (DSIP) and ACTH (4-10) analogue influence fos-induction in the limbic structures of the rat brain under emotional stress.Stress (Amsterdam, Netherlands) (2012)PMID 16539679Kovalzon VM, Strekalova TV · Delta sleep-inducing peptide (DSIP): a still unresolved riddle.Journal of neurochemistry (2006)HumanPMID 12668217Khvatova EM, Samartzev VN et al. · Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia.Peptides (2004)HumanPMID 12700031Obal F, Krueger JM · Biochemical regulation of non-rapid-eye-movement sleep.Frontiers in bioscience : a journal and virtual library (2004)HumanPMID 11437870Pollard BJ, Pomfrett CJ · Delta sleep-inducing peptide.European journal of anaesthesiology (2001)HumanPMID 9456470Steiger A, Holsboer F · Neuropeptides and human sleep.Sleep (1998)HumanPMID 8745061Seifritz E, Müller MJ et al. · Human plasma DSIP decreases at the initiation of sleep at different circadian times.Peptides (1996)HumanPMID 1475566van Kammen DP, Widerlöv E et al. · Delta sleep-inducing-peptide-like immunoreactivity (DSIP-LI) and delta sleep in schizophrenic volunteers.Sleep (1993)HumanPMID 2322843Tsunashima K, Masui A et al. · The effect of delta sleep-inducing peptide (DSIP) and phosphorylated DSIP (P-DSIP) on the apomorphine-induced hypothermia in rats.Brain research (1990)PMID 2842706Vallet PG, Charnay Y et al. · Distribution and colocalization of delta sleep inducing peptide (DSIP) with corticotropin-like intermediate lobe peptide (CLIP) in the human hypophysis.Neuroscience letters (1988)HumanPMID 3367267Noteborn HP, Graf MV et al. · Purification and characterization of DSIP-like material from ovine pineal glands: possible peptide-protein interaction.Journal of pineal research (1988)PMID 3286557Yehuda S, Carasso RL · DSIP--a tool for investigating the sleep onset mechanism: a review.The International journal of neuroscience (1988)HumanPMID 3620931Susić V, Masirević G et al. · The effects of delta-sleep-inducing peptide (DSIP) on wakefulness and sleep patterns in the cat.Brain research (1987)PMID 3550726Graf MV, Kastin AJ · Delta-sleep-inducing peptide (DSIP): an update.Peptides (1987)HumanPMID 3792404Schneider-Helmert D · Efficacy of DSIP to normalize sleep in middle-aged and elderly chronic insomniacs.European neurology (1987)Human

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