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Home/Compounds/Epithalon
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Epithalon

Also known as: Epitalon · Epithalone · AEDG peptide

Synthetic tetrapeptide studied for telomerase activation and potential anti-aging effects.

C
Grade C
Animal studies only
Human studies12
PubMed citations30
Typical dose5 mg – 10 mg
Routesubcutaneous, intramuscular
Regulatory (US)Compounding legal
Last verified4 days ago
TL;DR · 30-second summary
  • Increased telomerase activity in cell cultures
  • Extended lifespan in animal models
  • Improved melatonin regulation in elderly
  • Potential immunomodulatory effects

Mechanism of action

Stimulates pineal gland production of telomerase, which lengthens telomeres. May also regulate melatonin production and have immunomodulatory effects.

Evidence summary

12
Human studies
30
PubMed citations
0
Clinical trials
C
Evidence grade

Limited human trials show telomerase activation and potential longevity benefits. Most data from Russian research groups. Animal studies show lifespan extension.

Dosing protocols

Educational information only. Consult a licensed provider before using any peptide.
Dose range
5 mg – 10 mg

Typically 5-10mg daily for 10-20 days, repeated 2-3x yearly. Some protocols use lower doses for longer periods.

Administration routes
subcutaneousintramuscular

Side effects & safety

Reported side effects
Injection site reactionsGenerally well tolerated in limited human data
Contraindications
  • Active cancer (theoretical - telomerase concern)
  • Pregnancy

Interactions

No documented drug interactions on file.

Regulatory status

United States
Not FDA approved

Not FDA approved. Research chemical only.

Compounding
Permitted

Available through compounding pharmacies with valid prescription.

Regulatory data last verified 4/17/2026

Clinical trials

No indexed ClinicalTrials.gov studies for Epithalon. This usually means the compound isn't being studied under an IND — check the citations section for peer-reviewed research instead.

Citations

PMID 41490200Rahman OF, Lee SJ et al. · Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews (2026)HumanPMID 39788414Ullah S, Haider Z et al. · Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development.Life sciences (2025)PMID 40141333Araj SK, Brzezik J et al. · Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.International journal of molecular sciences (2025)HumanPMID 37042594Lezhava T, Jokhadze T et al. · EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON THE "OLD" CHROMATIN.Georgian medical news (2023)HumanPMID 32019204Khavinson V, Diomede F et al. · AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.Molecules (Basel, Switzerland) (2020)HumanPMID 31677028Sinjari B, Diomede F et al. · Short Peptides Protect Oral Stem Cells from Ageing.Stem cell reviews and reports (2020)HumanPMID 28976150Korenevsky AV, Milyutina YP et al. · [Protective effect of melatonin and epithalon on hypothalamic regulation of reproduction in female rats in its premature aging model and on estrous cycles in senescent animals in various lighting regimes].Advances in gerontology = Uspekhi gerontologii (2019)PMID 24423684Dzhokhadze TA, Buadze TZh et al. · [Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives)].Georgian medical news (2014)HumanPMID 22816096Khavinson VKh, Linkova NS et al. · Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture.Bulletin of experimental biology and medicine (2013)PMID 19110597Vinogradova IA, Bukalev AV et al. · Geroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens.Bulletin of experimental biology and medicine (2009)PMID 18856211Vinogradova IA, Bukalev AV et al. · Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.Bulletin of experimental biology and medicine (2008)PMID 17955380Sibarov DA, Vol'nova AB et al. · Effects of intranasal administration of epitalon on neuron activity in the rat neocortex.Neuroscience and behavioral physiology (2008)PMID 16634527Kossoy G, Anisimov VN et al. · Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice.In vivo (Athens, Greece) (2006)PMID 16705247Lezhava T, Monaselidze J et al. · Anti-aging peptide bioregulators induce reactivation of chromatin.Georgian medical news (2006)HumanPMID 15723138Anisimov SV, Khavinson VKh et al. · Effect of melatonin and tetrapeptide on gene expression in mouse brain.Bulletin of experimental biology and medicine (2005)PMID 15455093Raikhlin NT, Bukaeva IA et al. · Expression of argyrophilic proteins in the nucleolar organizer regions of human thymocytes and thymic epitheliocytes under conditions of coculturing with vilon and epithalon peptides.Bulletin of experimental biology and medicine (2005)HumanPMID 15909815Anisimov VN, Popovich IG et al. · [Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)].Voprosy onkologii (2005)PMID 12937682Khavinson VKh, Bondarev IE et al. · Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.Bulletin of experimental biology and medicine (2004)HumanPMID 12942748Kost NV, Sokolov OIu et al. · [Effect of new peptide bioregulators livagen and epitalon on enkephalin-degrading enzymes in human serum].Izvestiia Akademii nauk. Seriia biologicheskaia (2003)HumanPMID 12195242Khavinson V, Razumovsky M et al. · Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.Neuro endocrinology letters (2003)Human

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