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Home/Compounds/IGF-1 LR3
Growth hormone

IGF-1 LR3

Also known as: Long R3 IGF-1 · Receptor Grade IGF-1

Modified IGF-1 analog with reduced binding to IGFBPs; extended half-life vs native IGF-1. Research chemical.

C
Grade C
Animal studies only
Human studies6
PubMed citations9
Routesubcutaneous, intramuscular
Regulatory (US)Research only
Last verified2 days ago

Mechanism of action

Recombinant IGF-1 with an N-terminal 13-amino-acid extension and Arg3 substitution that markedly reduces IGFBP binding, extending circulating half-life.

Evidence summary

6
Human studies
9
PubMed citations
0
Clinical trials
C
Evidence grade

Evidence summary in progress. See the citations section below for the underlying research papers.

Dosing protocols

Educational information only. Consult a licensed provider before using any peptide.
Administration routes
subcutaneousintramuscular

Side effects & safety

No FDA label or editorial side-effect profile is on file for this compound yet. See the clinical trials and citations sections for study-reported safety data.

Interactions

No documented drug interactions on file.

Regulatory status

United States
Not FDA approved

Not FDA approved. Sold as a research chemical for cell-culture use.

Compounding
Not permitted

Not available via 503A/503B compounding pharmacies.

Regulatory data last verified 4/19/2026

Clinical trials

No indexed ClinicalTrials.gov studies for IGF-1 LR3. This usually means the compound isn't being studied under an IND — check the citations section for peer-reviewed research instead.

Citations

PMID 41015370Yavuz E, Sağır MS et al. · Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration.International journal of biological macromolecules (2025)PMID 39679943White A, Stremming J et al. · IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.American journal of physiology. Endocrinology and metabolism (2025)HumanPMID 39610283Engel MG, Narayan S et al. · Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.Journal of Alzheimer's disease : JAD (2025)HumanPMID 37114757White A, Stremming J et al. · Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.Journal of developmental origins of health and disease (2023)HumanPMID 37261455Lu Z, Liu N et al. · Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris.Applied microbiology and biotechnology (2023)HumanPMID 32573852Jonker SS, Giraud GD et al. · Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep.FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2021)HumanPMID 21281823von der Thüsen JH, Borensztajn KS et al. · IGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype.The American journal of pathology (2011)HumanPMID 10370861Hill RA, Hunter RA et al. · Action of long(R3)-insulin-like growth factor-1 on protein metabolism in beef heifers.Domestic animal endocrinology (1999)PMID 9565625Richards RG, Walker MP et al. · Insulin-like growth factor-1 (IGF-1) receptor-insulin receptor substrate complexes in the uterus. Altered signaling response to estradiol in the IGF-1(m/m) mouse.The Journal of biological chemistry (1998)