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Home/Compounds/Mechano Growth Factor (MGF)
Growth hormone

Mechano Growth Factor (MGF)

Also known as: IGF-1Ec · MGF

Splice variant of IGF-1 expressed in skeletal muscle in response to mechanical load; research peptide.

C
Grade C
Animal studies only
Human studies25
PubMed citations30
Routesubcutaneous, intramuscular
Regulatory (US)Research only
Last verified2 days ago

Mechanism of action

Alternative splice isoform of IGF-1 (exon 4-5-6 arrangement unique to this variant). Endogenously produced in response to muscle damage; synthetic versions investigated for muscle repair.

Evidence summary

25
Human studies
30
PubMed citations
25
Clinical trials
C
Evidence grade

Evidence summary in progress. See the citations section below for the underlying research papers.

Dosing protocols

Educational information only. Consult a licensed provider before using any peptide.
Administration routes
subcutaneousintramuscular

Side effects & safety

No FDA label or editorial side-effect profile is on file for this compound yet. See the clinical trials and citations sections for study-reported safety data.

Interactions

No documented drug interactions on file.

Regulatory status

United States
Not FDA approved

Not FDA approved. Research chemical only.

Compounding
Not permitted

Not available via 503A/503B compounding pharmacies.

Regulatory data last verified 4/19/2026

Clinical trials

NCT07037420A Phase 2, Randomized, Double-blinded, Placebo-controlled, Dose Range-finding, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of ALXN2420, a Growth Hormone Receptor Antagonist, Administered Subcutaneously in Combination With Somatostatin Analogs in Adult Participants With AcromegalyRecruiting · Phase 2 · Acromegaly · n=60NCT00647478A Multicenter Study to Assess Differences Between Circulating Levels of IGF-I and IGFBP-3 in Patients With Sporadic Late-onset Alzheimer's Disease and Control Elderly Subjects.Completed · Alzheimer's Disease · n=693NCT07407101Optimization of Autologous Serum Eye Drops: Study of Filtration on Active Molecule Concentration in Patients With Dry Eye Disease (IFilCoSA)Not Yet Recruiting · N/A · Dry Eye Syndrome (DES) · n=10NCT03253263A Phase 2b, Multicenter, Randomized, Open-label, Two-Arm Study to Evaluate the Clinical Efficacy and Safety of OHB-607 Compared to Standard Neonatal Care for the Prevention of Bronchopulmonary Dysplasia, the Most Common Cause of Chronic Lung Disease of PrematurityRecruiting · Phase 2 · Bronchopulmonary Dysplasia · n=338NCT07271212Evaluation of the Scalp Skin Care Effects of Premium Revitalizing ElixirActive Not Recruiting · N/A · Scalp Health · n=60NCT06985121Evaluation of the Scalp Skin Care Effects of Premium Scalp Revitalizing Essence、Premium Scalp Revitalizing Essence 2、Premium Scalp Revitalizing Essence 3Completed · N/A · Scalp Health · n=60NCT02375620A Multicenter, Randomized, Open-Label, Dose-Response, Phase II Clinical Study of Pegylated Somatropin (PEG Somatropin) Injection to Treat SGA Children With Short Stature.Active Not Recruiting · Phase 2 · Short Stature Children Born Small for Gestational Age (SGA) · n=96NCT04730622Study of Parameters of Bone Fragility and Sarcopenia in Patients Undergoing Surgery for Fracture of the Femoral NeckRecruiting · Osteoporotic Fracture of Femur · n=100NCT04202094Follow-up of Fertility in Young Adults Who Did or Did Not Store Testicular Tissue Before Gonadotoxic Treatment for Fertility PreservationEnrolling By Invitation · N/A · Childhood Cancer · n=50NCT02583763Cardiac Displacement From Third Trimester to Early ChildhoodActive Not Recruiting · IUGR · n=61NCT06869486Insomnia´s Impact on DNA Stability, Cardio-metabolic Health and Lifestyle Behaviors: A Case-control StudyRecruiting · Insomnia · n=300NCT06850532Metabolic Health, IGF-1, and Cardiovascular Fitness Responses to High-intensity Interval Training and Moderate-intensity Continuous Training in Combination with Superimposed Neuromuscular Electrical StimulationCompleted · N/A · The Effects of Neuromuscular Electrical Stimulation on Exercise Performance · n=24

Showing 12 of 25 indexed studies. View all on ClinicalTrials.gov →

Citations

PMID 40652678Fernández Y, Molina P et al. · Radioluminescence properties of rare earth doped LiF-MgF2 compounds for fiber optic dosimetry.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (2025)PMID 33732968Song Y, Li L et al. · Surface modification of electrospun fibers with mechano-growth factor for mitigating the foreign-body reaction.Bioactive materials (2025)HumanPMID 40303009Ding L, Ren T et al. · Establishment of a Triplex qPCR Assay for Differentiating Highly Virulent Genotype I Recombinant Virus From Low-Virulence Genotype I and Genotype II African Swine Fever Viruses Circulating in China.Transboundary and emerging diseases (2025)PMID 40379124Lei L, Chen CY et al. · Mangiferin: A natural neuroprotective polyphenol with anti-inflammatory and anti-oxidant properties for depression.Progress in neuro-psychopharmacology & biological psychiatry (2025)HumanPMID 38193124Zhao Y, Zhang S et al. · Mechanochemical coupling of MGF mediates periodontal regeneration.Bioengineering & translational medicine (2024)HumanPMID 38998063Zhang SJ, Niu B et al. · Identification of Two Linear Epitopes on MGF_110-13L Protein of African Swine Fever Virus with Monoclonal Antibodies.Animals : an open access journal from MDPI (2024)PMID 35057284Quan PH, Antoniac I et al. · Fluoride Treatment and In Vitro Corrosion Behavior of Mg-Nd-Y-Zn-Zr Alloys Type.Materials (Basel, Switzerland) (2022)HumanPMID 34549742Dong J, Tümer N et al. · Extrusion-based 3D printed magnesium scaffolds with multifunctional MgF2 and MgF2-CaP coatings.Biomaterials science (2021)PMID 30317597Sha Y, Yang L et al. · MGF E peptide improves anterior cruciate ligament repair by inhibiting hypoxia-induced cell apoptosis and accelerating angiogenesis.Journal of cellular physiology (2020)HumanPMID 32772171Alagaratnam S, Loizidou M et al. · Increased expression of IGF-1Ec with increasing colonic polyp dysplasia and colorectal cancer.Journal of cancer research and clinical oncology (2020)HumanPMID 28599103Song Y, Xu K et al. · The use of mechano growth factor to prevent cartilage degeneration in knee osteoarthritis.Journal of tissue engineering and regenerative medicine (2019)HumanPMID 28551627Christopoulos PF, Papageorgiou E et al. · The COOH-terminus of the IGF-1Ec Isoform Enhances the Proliferation and Migration of Human MCF-7 Breast Cancer Cells.Anticancer research (2017)HumanPMID 27931832Armakolas N, Armakolas A et al. · The role of the IGF-1 Ec in myoskeletal system and osteosarcoma pathophysiology.Critical reviews in oncology/hematology (2017)HumanPMID 27571686Armakolas N, Dimakakos A et al. · Possible role of the Ec peptide of IGF‑1Ec in cartilage repair.Molecular medicine reports (2017)HumanPMID 25569803Armakolas A, Kaparelou M et al. · Oncogenic Role of the Ec Peptide of the IGF-1Ec Isoform in Prostate Cancer.Molecular medicine (Cambridge, Mass.) (2016)HumanPMID 24908137Doroudian G, Pinney J et al. · Sustained delivery of MGF peptide from microrods attracts stem cells and reduces apoptosis of myocytes.Biomedical microdevices (2015)HumanPMID 20494600Dai Z, Wu F et al. · IGF-IEc expression, regulation and biological function in different tissues.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society (2011)HumanPMID 20087293Bachl N, Derman W et al. · Therapeutic use of growth factors in the musculoskeletal system in sports-related injuries.The Journal of sports medicine and physical fitness (2011)HumanPMID 20844834Milingos DS, Philippou A et al. · Insulinlike growth factor-1Ec (MGF) expression in eutopic and ectopic endometrium: characterization of the MGF E-peptide actions in vitro.Molecular medicine (Cambridge, Mass.) (2011)HumanPMID 19883387Velloso CP, Harridge SD · Insulin-like growth factor-I E peptides: implications for aging skeletal muscle.Scandinavian journal of medicine & science in sports (2010)Human

Showing 20 of 30 papers. View all on PubMed →