DATABASE · 2,000+ PEER-REVIEWED CITATIONS INDEXEDCOMPOUND LIBRARY · 100+ EVIDENCE-GRADED RECORDSGRADE A EVIDENCE · 45 COMPOUNDS WITH MULTIPLE HUMAN RCTSHUMAN EVIDENCE · 97 COMPOUNDS WITH HUMAN STUDY DATAVENDOR DIRECTORY · 11 RESEARCH VENDORS TRACKEDCLINIC DIRECTORY · 10 TELEHEALTH PROVIDERS VETTEDCOA RECORDS · 7 BATCH CERTIFICATES ON FILELIVE DATABASE · UPDATED 2D AGODATABASE · 2,000+ PEER-REVIEWED CITATIONS INDEXEDCOMPOUND LIBRARY · 100+ EVIDENCE-GRADED RECORDSGRADE A EVIDENCE · 45 COMPOUNDS WITH MULTIPLE HUMAN RCTSHUMAN EVIDENCE · 97 COMPOUNDS WITH HUMAN STUDY DATAVENDOR DIRECTORY · 11 RESEARCH VENDORS TRACKEDCLINIC DIRECTORY · 10 TELEHEALTH PROVIDERS VETTEDCOA RECORDS · 7 BATCH CERTIFICATES ON FILELIVE DATABASE · UPDATED 2D AGO
Home/Compounds/Thymulin
Healing

Thymulin

Also known as: Zn-FTS · Facteur Thymique Sérique

Zinc-binding thymic hormone (nonapeptide) studied for immunomodulation.

C
Grade C
Animal studies only
Human studies25
PubMed citations30
Regulatory (US)Research only
Last verified2 days ago

Mechanism of action

Nonapeptide requiring bound zinc for biological activity. Secreted by thymic epithelial cells; modulates T-cell differentiation.

Evidence summary

25
Human studies
30
PubMed citations
0
Clinical trials
C
Evidence grade

Evidence summary in progress. See the citations section below for the underlying research papers.

Dosing protocols

Educational information only. Consult a licensed provider before using any peptide.

Side effects & safety

No FDA label or editorial side-effect profile is on file for this compound yet. See the clinical trials and citations sections for study-reported safety data.

Interactions

No documented drug interactions on file.

Regulatory status

United States
Not FDA approved

Not FDA approved. Research peptide.

Compounding
Not permitted

Not available via 503A/503B compounding pharmacies.

Regulatory data last verified 4/19/2026

Clinical trials

No indexed ClinicalTrials.gov studies for Thymulin. This usually means the compound isn't being studied under an IND — check the citations section for peer-reviewed research instead.

Citations

PMID 37529610Savino W, Lepletier A · Thymus-derived hormonal and cellular control of cancer.Frontiers in endocrinology (2023)HumanPMID 37633587Lunin SM, Novoselova EG et al. · Protective effect of exogenous peroxiredoxin 6 and thymic peptide thymulin on BBB conditions in an experimental model of multiple sclerosis.Archives of biochemistry and biophysics (2023)HumanPMID 32577505da Silva AL, de Oliveira GP et al. · Nanoparticle-based thymulin gene therapy therapeutically reverses key pathology of experimental allergic asthma.Science advances (2022)HumanPMID 30388808Atabiekov I, Hobeika E et al. · The Role of Gene Therapy in Premature Ovarian Insufficiency Management.Biomedicines (2020)HumanPMID 30851702Nasseri B, Zaringhalam J et al. · Thymulin treatment attenuates inflammatory pain by modulating spinal cellular and molecular signaling pathways.International immunopharmacology (2019)HumanPMID 25662754Lunin SM, Khrenov MO et al. · Modulation of inflammatory response in mice with severe autoimmune disease by thymic peptide thymulin and an inhibitor of NF-kappaB signalling.International immunopharmacology (2016)PMID 25045213Novoselova EG, Khrenov MO et al. · Anti-inflammatory effects of IKK inhibitor XII, thymulin, and fat-soluble antioxidants in LPS-treated mice.Mediators of inflammation (2015)HumanPMID 24588820Reggiani PC, Schwerdt JI et al. · Physiology and therapeutic potential of the thymic peptide thymulin.Current pharmaceutical design (2015)HumanPMID 22861065Safieh-Garabedian B, Mayasi Y et al. · Targeting neuroinflammation for therapeutic intervention in neurodegenerative pathologies: a role for the peptide analogue of thymulin (PAT).Expert opinion on therapeutic targets (2013)HumanPMID 21952687Reggiani PC, Poch B et al. · Thymulin-based gene therapy and pituitary function in animal models of aging.Neuroimmunomodulation (2012)HumanPMID 21360440Martines E, Reggiani PC et al. · Neonatal thymulin gene therapy in nude mice: Effects on the morphology of the pituitary corticotrope population.Histology and histopathology (2011)PMID 21212643Martines EV, Reggiani PC et al. · Thymulin gene therapy prevents the histomorphometric changes induced by thymulin deficiency in the thyrotrope population of mice.Cells, tissues, organs (2011)PMID 18476235Dardenne M, Pleau JM · Interactions between zinc and thymulin.Metal-based drugs (2011)HumanPMID 19236333Reggiani PC, Morel GR et al. · The thymus-neuroendocrine axis: physiology, molecular biology, and therapeutic potential of the thymic peptide thymulin.Annals of the New York Academy of Sciences (2009)HumanPMID 18054190Prasad AS · Clinical, immunological, anti-inflammatory and antioxidant roles of zinc.Experimental gerontology (2008)HumanPMID 17192563Dardenne M, Saade N et al. · Role of thymulin or its analogue as a new analgesic molecule.Annals of the New York Academy of Sciences (2007)HumanPMID 17389714Goya RG, Reggiani PC et al. · Thymulin gene therapy prevents the reduction in circulating gonadotropins induced by thymulin deficiency in mice.American journal of physiology. Endocrinology and metabolism (2007)HumanPMID 12110619Safieh-Garabedian B, Dardenne M et al. · Potent analgesic and anti-inflammatory actions of a novel thymulin-related peptide in the rat.British journal of pharmacology (2003)HumanPMID 11359445Yara S, Kawakami K et al. · FTS reduces bleomycin-induced cytokine and chemokine production and inhibits pulmonary fibrosis in mice.Clinical and experimental immunology (2001)HumanPMID 10556775Hinojosa L, Chavira R et al. · Effects of thymulin on spontaneous puberty and gonadotrophin-induced ovulation in prepubertal normal and hypothymic mice.The Journal of endocrinology (1999)Human

Showing 20 of 30 papers. View all on PubMed →